Necrosis or ulceration (for example osteoporosis or ulcers in the small curvature of the stomach) occurs during the active phase of special biological programs relaying through the cerebrum.

In the case of the cerebral medulla, this means there is tissue deterioration by cell loss during an active self-devaluation conflict. In the case of the cerebral cortex, there is tissue deterioration by cell loss during active separation conflicts, hyper- or hypo-glycemia conflicts, and certain temporal lobe conflicts.

Usually “necrotization” refers to tissue loss in cerebral medulla (new mesoderm) tissues and “ulceration” is used for cerebral cortex (ectoderm) tissues. 

When the biological conflict in the psyche is resolved, the lost tissue is replenished through cell proliferation, often to a stronger and more sensitive condition than before. This can be accompanied by significant pain, stiffness, and weakness for cerebral medulla programs, and rash/inflammation for cerebral cortex programs.